Detroit Institute of Arts Museum

The concept used for surgical primary therapy of endometrial cancer is described. This S3-guideline on endometrial cancer is intended as a basis for certified gynecological cancer centers. This can significantly reduce therapy-induced morbidity and improve the patientʼs quality of life as well as avoiding unnecessary costs. Funded by German Cancer Aid as part of an Oncology Guidelines Program, the lead coordinators of the guideline were the German Society of Gynecology and Obstetrics (DGGG) and the Gynecological Oncology Working Group (AGO) of the German Cancer Society (DKG).

They are flying under the radar of their teachers and parents, even as their growing brains are being rearranged each time they are told, “You can’t play.” At the same time, we often dwell in the Land of Regret, wailing: “If only!” Dan Ariely has been on a roll with the study of irrationality in recent years. Gigerenzer invites us on a journey into a largely neglected Land of Irrationality—populated by folks who are partially ignorant, whose time is limited, and whose future uncomfortably uncertain. In his ground-breaking book, GUT FEELINGS: THE INTELLIGENCE OF THE UNCONSCIOUS, he points out how how much of our mental life is grounded in processes alien to logic—gut feelings and intuitions.

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dr gerd wesselmann

She also discusses her approach during this improvement season and what she thinks of the growth and time to build and how she is treating/speaking to herself differently. Tune in to hear Annabel talk about how modeling impacted her mindset, how the modeling industry treated weight and size, how moving to a culture that accepted women with more size opened her world up to bodybuilding, and how she is making an impact in the sport there now. All while embracing a positive mindset, deciding to make a change, and even gain insight from how she utilizes visualization and speaks her dreams into existence not only in bodybuilding but also in her life and business.

As a company that offers advice to local farmers and at the same time imports organically grown plant products, africrops! At the same time, the development of local markets is also supported: The farm is not only intended to cover its own needs for vegetables, but aims at creating a sustainable income through the sale of high-value organic vegetables on the local market. Heinrich Heinrichs travelled to Namibia for the second time this year to accompany the setting-up of a vocational training center in collaboration with the Namibian Training Authority (NTA) and the Komeho Development Agency. On the programme were further visits to German companies, including to a company that is involved in the packaging of africrops! It was sponsored by the German Federal Ministry for Economic Cooperation and Development (BMZ) and the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ).

  • One artist, Michael Rakowitz, turned down the invitation to participate in response to the presence of the Whitney’s vice chair at the time, Warren Kanders, CEO of Safariland.
  • Vaginal dilators may be used for treatment of and prophylaxis against vaginal stenoses in patients with endometrial cancer, after the completion of radiotherapy and resolution of the acute sequelae of radiotherapy.
  • The patient must be offered the opportunity to bring along her partner or a relative/trusted confidant to any talks, starting with when she is given the diagnosis and including all following discussions and meetings during therapy and follow-up.
  • The training center is located in the Omaheke region in the East of the country and is accompanied on site by the africrops!

Three independent factors predicted adherence in a randomized controlled trial of resistance exercise training among prostate cancer survivors. Effectiveness of core stability exercises and recovery myofascial release massage on fatigue in breast cancer survivors: a randomized controlled clinical trial. Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial.

dr gerd wesselmann

During the consultation with her physician, the patientʼs individual preferences, needs, worries and fears must be elicited and taken into account. Providing generally intelligible data about associated risks (e.g., information on the reduction of risk in absolute figures) supports the patient and allows her to make an independent decision for or against medical measures. Cancer patients and their relatives must be informed as early as possible about the available options for psychosocial support, counseling and treatment; they must be informed during all stages of disease and must be helped to access these options based on their individual needs. There can be no doubt, however, that this cases meets the criterion “life-threatening disease”.

Welcome to the life of a junior doctor: 97-hour weeks, life and death decisions, a constant tsunami of bodily fluids, and the hospital parking meter earns more than you. In just a fraction of that time, one species among countless others has conquered it.

Case 2: acute asthma – significance of the “art of observation” (remedy: Bryonia) This timeline is where you’ll spend most of your time, getting instant updates about what matters to you. Brandi Sillerud who has been invited to participate as a panelist at the MN-HFMA Women of Influence Conference on January 23, 2019. we believe in fair trade instead of aid as an effective tool to promote a sustainable socio-economic development in Africa. The project, which is being implemented by the Gesellschaft für Internationale Zusammenarbeit (GIZ), aims to promote moringa as a dietary supplement for pregnant and breastfeeding women and children under the age of […]

dr gerd wesselmann

Max Planck Institute for Human Development

Moreover, silencing of the gene affected the cyst germination and penetration of germ tube into the host tissues, and led to the reduced virulence of P. capsici. Thus, we suggest that PcLRR-RK1 was essentially required for zoospores development, and successful infection of the P. capsici.

Efficacy of an anatomic approach in a large cohort of patients with atrial fibrillation. Figure 5 Pulmonary resistance at rest, at 50 W, and at the mean maximum exercise level of 100±37 W.

The sequences of LGI3 orthologues were analyzed from various species, and it was found that LGI3 was highly conserved in mammals and that the subsets of amino acid residues were phylogenetically coevolved in four major clusters. Single nucleotide polymorphisms (SNPs) of the human LGI3 gene included 228 functionally relevant variants (missense, nonsense and frameshift) in a total of 1,042 SNPs. Four missense SNPs had a global minor allele frequency ≥0.001.

SG right heart catheterization

Pathologically, PD is characterized by selective loss of dopaminergic neurons in the substantia nigra and the formation of intracellular inclusions containing α-synuclein and ubiquitin called Lewy bodies. Consequently, a remarkable deficiency of dopamine in the striatum causes progressive disability of motor function. The etiology of PD remains uncertain. Genetic variability in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of sporadic and familial PD. LRRK2 encodes a large protein containing three catalytic and four protein-protein interaction domains.

The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth

Ler/Ws, ecotype-specific deletion of five amino acid residues (SKLPE; overlined); six helices predicted by MacVector program are underlined; 18 amino acids deleted in allele DEI284 are overlined; the predicted supernumerary helix 4a (H4a) of allele UU3025 is indicated by a broken line. Only the homologous region of HsXRP2 is shown. (b) HAL/HsArl2. Allele EIC8 has a deletion of 15 bp including a splice donor site (∇).

In addition, patients with BE require minimum of 8 biopsies. It is also proposed that endoscopists should utilize the Prague classification to describe what is seen in the Barrett segment (29). A recent study evaluated cost effectiveness of screening patients with GERD for BE with a minimally invasive cell sampling device called Cytosponge (30). The screening was found to be cost effective. There is a 5-year survival in 83% to 90% of the cases for EAC, if the tumor is identified at an early stage whereas a dismal 10% to 15% 5-year survival exists for those with late-stage cancers (28).

Lessons learned by use of magnetic resonance imaging. Saad EB, Rossillo A, Saad CP, Martin DO, Bhargava M, Erciyes D, Bash D, William-Andrews M, Beheiry S, Marrouche NF, Adams J, Pisanò E, Fanelli R, Potenza D, Raviele A, Bonso A, Themistoclokis S, Brachmann J, Saliba WI, Schweikert RA, Natale A. Pulmonary vein stenosis after radiofrequency ablation of atrial fibrillation.

Phylogenetic analysis points to their diversification into two families namely TIR-NBS-LRR and non-TIR-NBS-LRR. Gene architecture revealed intron gain/loss events in this resistance gene family during their independent evolution into two families.

A recent Markov analysis by Hur and colleagues suggests that RFA is cost effective in preventing the progression of HGD to cancer compared with surveillance (34). They suggest a role for ablation in confirmed, stable, and multifocal LGD.

The published annotation ( was corrected as indicated below. Identical amino acids are highlighted by black, similar ones by gray shading. Genomic sequence changes in mutant alleles (designations indicated above the sequences) are shown as amino acid replacements, asterisks (stop codons) or open triangles (splice sites affected). (a) POR/HsTFC C/HsXRP2.

(c) PFI/HsTFC E. Exons 1, 5, and 14-16 (corresponding to amino acids 1-103, 226-250, and 448-531, respectively) have been added and intron 2 inserted (between amino acids161 and 162); CAP-Gly domain is boxed (amino acids 32-76); nine leucine-rich repeat (LRR 1-9) motifs are indicated by dots above critical residues (amino acids 159-384); Q(207) → E and V(347) → L, Ler polymorphism; arrow indicates break point of 10-Mb inversion in allele ML375. (d) KIS/HsTFC A. The second exon has been shortened by 66 bp, now corresponding to amino acids 52-80, and a third exon added, corresponding to amino acids 81-113; three helices (determined by structure analysis of homologous Rbl2p from yeast; Steinbacher 1999) are underlined; (ββ) conserved residues DC that influence β-tubulin binding in TFC A (Llosa et al. 1996); splice site mutations insert 12 amino acid residues (INYIFHCYCLLS) between helix 2 and 3; allele MM240 (not indicated) has a deletion of the entire gene and 80 kb of flanking DNA. (e) CHO/HsTFC D. A donor splice site shifted by 15 bp adds amino acid residues 1077-1081, VPCLQ (overlined); R(237) → G, Ler polymorphism.

Whether patients with one stenosed PV and no or only few clinical symptoms need invasive therapy to prevent pulmonary hypertension may be answered by prospective randomized studies. None of the 11 patients had pulmonary hypertension at rest. However, during exercise seven patients had pulmonary hypertension. Three of these seven patients had simultaneous augmentation of PA and PCP pressures, likely caused by left ventricular dysfunction.

Continuing attention is being devoted to the development of substitute strategies in plant-disease management and reducing dependency on synthetic chemicals. Viral, fungal and bacterial diseases are unquestionably the most versatile for environmental adaption and in the destruction of plant growth. Among the strategies, resistance breeding has generated proven data and been exploited in depth. However, conventional methods alone are not sufficient to control the novel races of viral, fungal and bacterial pathogens in crops due to a scarcity in required crop variations.

The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel beta-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs. The structure can serve as a model for the interactions of other proteins containing leucine-rich repeats with their ligands. During an evolution of many years, a gradual shift occurs from LGD to HGD, intramucosal cancer, and lethal disease. The obligation of the endoscopist is to properly identify each of these stages and assign appropriate therapy.

The total follow-up time since the ablation procedure in these 11 patients was 50±15 months (median 49, interquartile range 43-60). Written informed consent was obtained from all patients. The nucleotide binding site-leucine rich repeat (NBS-LRR) proteins play an important role in the defense mechanisms against pathogens. Using bioinformatics approach, we identified and annotated 104 NBS-LRR genes in chickpea.

gerd deisenhofer

National Institute of Diabetes and Kidney and Digestive Diseases

However, even the more industrialized countries of Serbia and Croatia suffer from weak university-industry linkages. Strong growth in the number of doctorate-holders has enabled researcher density to grow in most countries. The expenditure on intramural Development and Research increased in all the four sectors. In particular, the Business enterprises expenditure on R&D (BERD) registered a 7.5% increase on the previous year, the Higher education sector a +6.5%, the national government a +0.8% and the Private non-profit sector a +5.5%.

Total intramural R&D expenditure (GERD) comprises current costs and capital expenditure on R&D. All data are broken down by the above mentioned sectors of performance. The R&D expenditure is broken down by source of funds further, by type of costs, by economic activity (NACE Rev.2), by size class, by type of R&D, by fields of science, by socio-economic objectives and by regions (NUTS 2 level). Gross domestic expenditure on R&D (GERD) is total intramural expenditure on R&D performed in the national territory during a specific reference period.

In a minor number of countries, micro enterprises with less than 10 employees where R&D activity is expected to be negligible are excluded from the R&D surveys. However, this has only a minor impact on the aggregated data.

Venture Capital Investment (VCI) is the subset of private equity which is intended for investments in listed companies and firms which develop new products and technologies. VCI serves as the early stage funding (seed and start-up), or it is used for expansion of a venture (later venture). Data from national R&D surveys based on the Frascati Manual, OECD,

R&D Innovation

They also provide the accounting system within which the institutional classifications and functional distributions may be applied. The website provides a set of indicators describing the progress made by Belgium and its Regions in the field of innovation. The Federal has developed The website Planning Bureau at the request of the Belgian Science Policy Office, following the Federal Government’s decision to create a transversal technology platform. The percent of GDP dedicated to R&D is the most significant indicator which notifies about the level of economic innovation in a particular country. The table below published by Eurostat depicts the data concerning Venture Capital Investment (code VENTURE) which is expressed as GDP (Gross Domestic Product at market prices).

Data in these fields collected by Eurostat serves both scientists and policymakers. In 2009 the total amount of the expenditure on research and development activity (R&D) is 361.1 million BGN which increases by 10.8% in comparison with the previous year and the annual growth tendency retains for the period of 2005 – 2009. In 2010 the total amount of the expenditure on research and development activity (R&D) is 420.1 million BGN which increases by 16.4% in comparison with the previous year and the annual growth tendency retains for the period of 2006 – 2010. In 2013, the total amount of expenditure on research and development activity (R&D) was 521.2 million BGN which was 5.0% more than the previous year.

total intramural r d expenditure gerd

“Research and experimental development (R&D) comprise creative and systematic work undertaken in order to increase the stock of knowledge – including knowledge of humankind, culture and society – and to devise new applications of available knowledge “(Frascati Manual, 2015 edition, par 44). Domain comprises national statistics on R&D expenditure, R&D personnel and government budget appropriations or outlays on R&D (GBAORD). Data are collected in several occasions in a year and they consist of several breakdowns such as institutional R&D performing and funding sectors, types of costs and types of R&D, fields of science and economic activities.

The R&D intensity amounted to 0.64% of GDP and was by 0.07 percentage points higher compared to 2011. The private component of expenditure on the intramural R&D (Business enterprises+Private non-profit sector) increased, rising from 57.7% of total R&D spent in 2013 to 58.3% in 2014. The contribution of government fell by 0.7 percentage points (from 14.0% to 13.3%). The contribution of the Higher education sector remained quite stable (from 28.3% to 28.4%).

total intramural r d expenditure gerd