phorbol esters (Feri et al., 1989), and can inhibit cell proliferation in a reversible and dose-dependent way. The anticancer activity has been linked to the presence of type II EBS receptors, for which quercetin shows selective afﬁnity. The cytotoxicity is synergically magniﬁed by the combination with genistein, and quercetin was also effective at reversing resistance to adriamicin.
The very high batch-to-batch reproducibility is presumably due to the poor genetic variation of sugarcane and in general of crop plants. This is potentially dangerous from an agricultural standpoint, but is undoubtedly an important asset for the pharmaceutical exploitation of these plants. The composition of policosanol can be assessed by GCanalysis after silylation. The major constituent is 1-octacosanol (17a, 60-70 per cent), accompanied by its higher and lower homologues (1-triacontanol (17b, 10-115 per cent) and 1-hexadecanol (17c, 4.5-10 per cent). consumption can induce tumour formation in the gastrointestinal tracts of rodents seem ﬂawed by the exorbitant doses employed (150 mg/kg per day, over 100 times the average human consumption in tropical countries, where cuisine
In glycosidic form it is almost ubiquitous in fruits and vegetables, with signiﬁcant amounts occurring in onions, tomatoes and apples as well as in wine (Hertog et al., 1992). With the exception of onions, quercetin generally occur in skin tissues. On average, the human diet contains almost 1 g ﬂavonoid per day, and ﬂavonoids have been implicated in the protective effect of the consumption of large amounts of fruits and vegetables against cancer and heart diseases. Evidence for this correlation is, at present, weak, especially as regards the chemopreventive activity (Hollman and Katan, 1999).
Dohrn IM. Physical activity and health-related quality of life in older adults with osteoporosis. Inst för neurobiologi, vårdvetenskap och samhälle/Dept of Neurobiology, Care Sciences and Society; 2015 Aug 26.
This striking finding contrasts with the situation in some counties such as in Europe where girls are more likely to smoke (and in some cases to engage in ‘heavy episodic’ or ‘binge’ drinking) than boys.26-28 In fact, the levels of youthful alcohol use reported in this study were lower than those noted by earlier research in Vietnam.29 It should be noted that the present study related only to North Vietnam. It is possible that alcohol consumption is heavier in other parts of the country. The sample design utilised in this study is shown in Table 1.
Recall bias may have also produced an overestimation of maternal deaths if some respondents incorrectly attributed deaths of sisters to maternal factors. CENTRAL ASIAN JOURNAL OF GLOBAL HEALTH previous tobacco studies among students.14,15 Almost 37.20% of tobacco smokers in our study reported that they had started tobacco smoking because of curiosity. Unstable relationships among family members were also a factor for continuing to smoke tobacco.
Sayeed et al.20 in Bangladesh found the prevalence of diabetes was 6.80% according to fasting blood glucose (FBG) guideline values. In the present study, we found that only BMI ≥ 25 was significantly associated with GDM, while Sheshiah et al.25 found that age ≥ 25 years, BMI ≥ 25 kg/m2, and positive family history of diabetes were significantly associated with GDM. Rajput et al.24 found that socioeconomic status above upper middle class and Kalra et al.22 found that family history of diabetes mellitus, age ≥ 25 years, past history of GDM, and BMI ≥ 25 kg/m2 were significantly associated with GDM group. Rajput et al.24 found that socioeconomic status above upper middle class was associated significantly with GDM in their findings. Kalra et al.22 found that a family history of diabetes mellitus, age ≥ 25 years, past history of GDM, and BMI ≥ 25 kg/m2 were significantly associated with GDM group in their study.
- Existing studies in India were done at different geographic locations and in different time periods.11 A recently published report indicated that new and more rigorous research and surveillance studies are needed in India to assess the extent of NCD burden.12 Due to scarce national level data, there is a lack of effort to initiate policy changes for controlling the CVD epidemic.13 However, a few public health sentinel surveys have found that a cluster of major risk factors (tobacco, alcohol, inappropriate diet, and physical inactivity) govern the occurrence of CVDs in India.14 Studies have also found that rapid dietary changes associated with a decrease in levels of physical activity also play a particularly important role in the increasing incidence of cardiovascular diseases.15 The purpose of this multi-site study was to determine the contribution of several socioeconomic and lifestyle factors to cardiovascular diseases among the adult male population of India.
- The authors thank Sean P. Soisson for comments on an earlier version of this manuscript.
- Plasma glucose was measured with the use of the hexokinase-glucose 6-phosphate dehydrogenase enzymatic assay (Sigma Diagnostics, St. Louis, MO), and insulin concentration was measured by a radioimmunoassay kit (Linco Research, St. Charles, MO).
- OGTT is supposed to be performed under clinical observation with laboratory set up.
- Consumers must get closer to the science of nutrition to fully get the power hidden in functional foods, and scientists must put all their effort into making simpler what indeed is still a complicated molecular puzzle.
55.49% of participants in the present study were 21-25 years of age, and 60.98% were illiterate. In a similar study by Rajput et al.24 58.20% were 21-25 years of age, while only 4.90% were illiterate. Literacy rate in the present study was low as compared to national average (65.46%) and Gujarat state average (70.73%) for females.26 The reason may be due to the fact that the selected district was in a remote area with tribal vicinity. Vietnam has no minimum legal age for purchasing alcohol and it is very easy for young people to get alcohol anywhere that it is on sale. Initiation into alcohol consumption occurred at an early age, even before the age of 18, particularly amongst males.
As the major dietary ﬂavonoid, quercetin has been extensively investigated as a pharmacological agent (Jiyun et al., 1997). Quercetin shows all the key structural elements underlying the radical-stabilizing properties of ﬂavonoids, namely the 3hydroxyl and the oleﬁn bond in the heterocyclic ring and the catechol system on ring B. The presence of the 4-oxo-3,5-dihydroxy moiety also guarantees excellent metalbinding properties, and, unsurprisingly, quercetin shows very high antioxidant activity, with a TEAC index comparable to that of epigallocatechin gallate (Pietta, 2000). These properties are, however, attenuated by glycosidation of the 3-hydroxyl, as commonly encountered in the natural form of quercetin. activity of gossypol is due to prevention of implantation in females and to destruction of the seminiferous tubules with consequent oligospermia in males.
The molecular mechanism is unknown. In in vitro assays, gossypol is a powerful inhibitor of lactate dehydrogenase, but it is not clear how this translates into the observed antifertility activity. In the 1990s, interest in gossypol was rekindled by the discovery of its antiproliferative effects, selective for cancer cells, and more pronounced for the (⫺) form compared to the racemate (Joseph et al., 1986).
Gossypol seemingly interacts with speciﬁc biological target(s), whose identity is, however, still elusive. Gossypol is also a remarkable example of a chirally axial compound where remarkable differences in biological activity exist between the two enantiomeric forms.
Ethnomedical plant-use data in many forms has been heavily utilized in the development of formularies and pharmacopoeias, providing a major focus in global healthcare, as well as contributing substantially to the drug development process (Graham et al., 2000). Table A.3 lists the results of a query of the Napralert database for plants which have been reported to have been used ethnomedically against cancer.