Antacid Tablet Using Back Titration
For comparison, a commercial antacid formulated with hydrotalcite (Baytalcid®) was tested. The results showed the same interaction with the pepsin molecule (Fig. 6). It can be concluded that this interaction is normal when formulated antacid is placed in contact with the pepsin.
How Powerful Is Your Antacid?
Some very common household solutions are acids, such as citrus fruit juices and household vinegar. Bases are solutions that pull hydrogen ions out of solution and onto themselves, “accepting” them, and usually feel slippery.
Thus, none of these remedies should be taken in large amounts or for a prolonged length of time. Each antacid must be taken with caution and dosage information printed on the label should be strictly followed.
+ MgO) is suspended in 300 ml of deionized water. The suspension is maintained at 37°C±1° and stirred at 300 rpm.
The interaction solid-pepsin was measured by UV-visible spectroscopy by means of an HP 8452A with diode arrangement, using a filtered aliquot from modified kaolin mixed with the synthetic gastric juice. The spectrum was recorded between 200 and 400 nm. Spectra were taken before and after contacting the solids with the synthetic gastric juice. Finally, FT-IR spectroscopy was applied to solids after the interaction with the synthetic gastric juice.
All calcium and sodium salts formed during the hydrothermal reaction remain occluded between layers of clay. These occluded salts can be used as “carbonate pump” allowing the dosage of carbonate against the acidity.
This fact corroborates the effective blockage of the porous of the clay by the presence of precipitated carbonate salts. Of course, if the sodium carbonate concentration used is very high, it is possible a major blockage of porous; however, according to ours experiences, the blockage of porous was possible in a high extension, using diluted sodium carbonate solutions. 3. The antacid powder of Claim 1 wherein all or part of the magnesium is replaced by calcium.
When mixed with water, whether a chemical “donates” a charged particle (called an ion) to the solution-in this case, a hydrogen ion-or “accepts” one from it determines whether it’s an acidic or basic solution. An indicator changes color when exposed to such a mixture, depending on whether the solution is acidic or basic.
In the quest for a better antacid many substances have been tried but no ideal agent has been found. Many virtues have been attributed to these compounds but as far as is known their chief value lies in their acid reducing property. We have, therefore, made analyses of some of the more commonly used substances on a basis in which their neutralizing capacity by titration can be compared with their antacid property within the human stomach. Another disadvantage of calcium carbonate may be the tendency for gastric acid secretion to rebound after calcium is given.
You will first react the antacid tablet with a known amount (volume) of the standardized HCl. Then you
Using calcium carbonate as an antacid (Tums or Rolaids) avoids many of the problems caused by sodium bicarbonate. Tums contain only calcium carbonate while Rolaids contains a combination of calcium carbonate and magnesium hydroxide.
The sample is titrated with 1.0N HCl at such a rate as to maintain a constant pH of 3.0, while recording on a strip chart the volume of acid used versus time. The titration is continued until no more acid is consumed. The times, in minutes, when 50% (T 50 ) and 90% (T 90 ) of the total antacid are consumed by the acid are determined.
Explore the properties and uses of antacids. Watch an “antacid in action” as it neutralizes simulated stomach acid. Determine the neutralizing ability of common over-the-counter antacids by titration and compare the neutralizing power and costs of various antacids. Student answers may vary.
Calcium Carbonate [CaCO3] – Calcium Carbonate (chalk) is the most potent usable antacid. It can completely neutralize stomach acid. Nonetheless, it is not always the best choice for regular use. Antacids are a group (class) of medicines which help to neutralise the acid content of your stomach.